How to control high blood pressure in a patient with chronic nephritis symptoms

In the early period of the patients with chronic nephritis or after illness tend to have high blood pressure symptoms appear, once appear, the high blood pressure do? Nothing can't be sure, this will only accelerate the progress of chronic nephritis, chronic glomerulonephritis hypertension to how to control?
Chronic nephritis, residual and (or) pathological changes of nephron compensatory high hemodynamic state, in systemic hypertension is aggravating this kind of condition, lead to glomerular progressive damage, therefore, should actively control of hypertension in patients with chronic nephritis, prevent the deterioration of renal function.
So why is chronic nephritis patients crisis will appear the phenomenon of high blood pressure?
First of all, the kidney is the main organ metabolism of water and sodium, chronic nephritis make kidney tissue damage and affect the kidney function, water, sodium excretion is disorder, cause water sodium retention. And this phenomenon has led to an increased blood volume, so that the blood pressure.
Again, as a result of kidney ischemia, the change of the renal vascular tension cause renin secretion increased, through the role of the renin - angiotensin, promote aldehyde sterol and vasopressin secretion increased, leading to the distal tubule absorbs water, sodium increases, this kind of situation will lead to increased blood pressure.
Have chronic kidney disease: why do you want to control high blood pressure?
Kidney is made up of many tiny blood vessels a viscera, used to filter toxins in the body, prevent leaking blood vessels such as proteins, blood cells at the same time. High blood pressure, if can not get good control for a long time, can lead to kidney inside tiny hardening of the arteries. This is why most of the patients with high blood pressure are associated with different levels of renal damage. This kind of damage if not treated in time, as the growth of the age, the development in the end will lead to glomerular sclerosis, renal interstitial fibrosis, eventually leading to renal insufficiency.
So, how to control high blood pressure, chronic nephritis? Angiotensin converting enzyme inhibitors as first-line antihypertensive drugs.
According to many clinical studies confirmed that calcium antagonists, such as benzene, pyridine, monica nitrate equal treatment of high blood pressure and slow deterioration of renal function have relatively definite curative effect. Research suggests that calcium antagonists despite a slight expansion goal the role of the small arteries, but because it has a significantly lower blood pressure, therefore, can make the intact or only part of the involvement of glomerular high hemodynamic and metabolic conditions improve.
In addition, calcium antagonists reduce oxygen consumption, platelet aggregation, and through the cell membrane effect to reduce calcium ion and reduce the sedimentation of the interstitial cell membrane excessive oxidation, so as to alleviate kidney damage and stable renal function.
Beta blockers, such as metoprolol, ammonia acyl reassuring, has good curative effect of renin dependency high blood pressure. Beta blockers have reduced renin effect, the drug is reduced the cardiac output, but does not affect the renal blood flow and GFR, therefore, also used in the treatment of renal hypertension. It should be noted that some beta blockers, such as ammonia acyl peace and naphthalene hydroxyl reassuring, low fat soluble, renal excretion, renal full-time dose adjustment should be paid attention to more and longer time.
In addition, the expansion of blood vessels drugs such as hydralazine have antihypertensive effect, it can be associated with beta blockers used, reduce the expansion of blood vessels stimulates renin angiotensin system such as side effects, such as the heart beats faster, water sodium retention), and can improve the effect of treatment. Hydralazine generally 200 mg per day, but the sample must be alert to the drug induced lupus erythematosus (sle) syndrome.
For patients with chronic kidney disease with edema, if renal function is good, can use plus thiazide diuretic; Memory of kidney (serum creatinine > 200 mu mol/L), thiazide drugs curative effect is poor or ineffective, should use medullary loop diuretics. Application of diuretics should pay attention to the body electrolyte disorder, and attention should be paid to tend to increase the hyperlipidemia and high coagulation state.
How to control high blood pressure in a patient with chronic nephritis symptoms? Above is our experts related introduction, if you still have what not understand of place, can consult our online experts. Xi 'an tongji kidney disease hospital opened a green channel network to make an appointment for you, the input problem, click the ask button, immediately ask professional nephrologist. Details please consult experts free telephone: 400-8899-8899 (mobile) free health advice 24 hours a day. Hospital address: xi 'an mayor annan road no. 16 (800 m) tower to the south.