Monday, June 3, 2013

How to Prevent and Control Diabetic Nephropathy?

There are many points which patients with Diabetic Nephropathy should pay attention to. In this passage, experts in Shijiazhuang Kidney Disease Hospital will introduce it for you in detail.
1. Patients with Diabetic Nephropathy should control the blood pressure strictly and control it below 130/80mmHg. In addition, it is forbidden to take medicine which does harm to kidney.
2. Smoking is also forbidden. Besides, high blood pressure, high blood glucose, and high protein should also be prevented.
3. Patients with Diabetic Nephropathy should take more water. The intake of water should be 1500-2000, and the amount of urine should also be 1500-2000, which is good to the discharge of metabolism.
4. Patients with Diabetic Nephropathy should control the intake of protein, the amount of which should be 0.6-0.8g/kg/day. In addition, patients should take in high quality protein food such as fish and lean meat.
5. Patients with Diabetic Nephropathy should control the intake of blood sugar as well. It is because high blood sugar can accelerate the development of Diabetic Nephropathy.
If people have been diagnosed with Diabetic Nephropathy, besides the above-mentioned points, they should also take effective measures so as to repair the damaged intrinsic cells and stop it from developing into end-stage Uremia.

Which Factors Lead to Diabetic Nephropathy 2013

Diabetic Nephropathy can not be found out at early stage. Once it is found, it has often been in advanced stage and has deteriorated. So which factors lead to Diabetic Nephropathy? They are as follows:
The first factor is the abnormal renal haemodynamics. Renal haemodynamics plays a critical role in the coming into being of Diabetic Nephropathy. When the blood sugar is high, the pressure in capillary wall will increase, which leads to the extension of mesangial area, the fusion of foot process of epithelial cells. The epithelial cells drop from renal basilar membrane, which leads to the ultrafiltration and ultraperfusion. Basilar IV collagen messenger increase, which leads to the increased thickness of basilar membrane. At last, diffusibility and nodositas will come into being, leading to sclerosis. With the increasing of dynamic pressure of renal blood flow, the filtration of protein increases, which leads to the increase of matrix. Nodositas renal glomerular sclerosis comes into being.
The second factor is high blood sugar. In most cases, the occurrence of Diabetic Nephropathy is related to high blood sugar. When the sugar in the blood is not controlled well, high blood sugar and increased adanced glycation end products can lead to the proliferation of mesangial cells and increased matrix. The mesangial area will extend, which can lead to the occurrence of Diabetic Nephropathy.
The third factor is high blood pressure. High blood pressure has no direct connection with Diabetic Nephropathy. But in the high blood pressure stage when there is microalbunminuria, the high blood pressure can lead to the deterioration of renal function, which causes Diabetic Nephropathy.
The fourth factor is genetic factors. People whose parents have had Diabetic Nephropathy are more likely to have Diabetic Nephropathy compared with those whose parents do not have Diabetic Nephropathy.
The fifth factor is the increased blood viscosity and the block of micro-circulation. Blood viscosity and the block of micro-circulation can lead to thrombus easily. Once thrombus comes into being, renal unites will be in the insufficiency of blood and oxygen. Protein in urine will increase and renal function will decline.
The sixth factor is high protein diet. It is also a factor which can bring more burden to the kidney, and cause vicious circle. So for patients with Diabetic Nephropathy, the intake of protein should not be more than 40g.
The last factor is hyperlipidemia, which is common among those with Diabetic Nephropathy. Hyperlipidemia can promote the renal glomerular sclerosis and accelerate the development of Diabetic Nephropathy.

Can Obesity Cause Diabetes

With the rapid development of the society and the improvement of life quality, some people have more body weight. And some may even develop into Diabetes. Diabetes is a kind of dangerous disease, which can accompany people in the whole lifetime. Is there any relationship between obesity and Diabetes? Yes. In this passage, we will mainly introduce you how obesity leads to Diabetes.
Firstly, as for those with increased body weight, because the adipocyte becomes fat, the density of insulin receptor in adipocyte becomes smaller, the sensibility to insulin decreases, which leads to high blood glucose. To stop the blood glucose from rising, patients will spare no effort to work and relieve more insulin, which can lead to hyperinsulinemia. With time passing by, insulin becomes tired, the function of which declines. The level of insulin in blood declines, and the blood sugar increases, which even leads to diabetes.
Secondly, for people who are heavier than the normal range, the amount of exercise will generally decrease, which lead to a fact that the body weight increase further. In addition, when people with obesity have less exercise, the metabolism of sugar will also decrease, which leads to increased sugar level in blood.
Thirdly, obesity people usually have high blood pressure and hyperlipidemia. It is found out that high blood pressure and high fat level in the blood are dangerous factors which can lead to Diabetes. As a matter of fact, other investigation from abroad also shows that people who are fat are more likely to get Diabetes. So to prevent Diabetes, we should firstly control the intake of energy, take more exercise, thus preventing obesity.
What shall we do if people are diagnosed with Diabetes?
In type 1 diabetes, the body’s immune system becomes programmed to attack the beta cells, so the patient must take immuno-suppressant drugs to prevent this happening.
Doctors and scientists have tried to cure the disease through injections of pancreatic islet cells. Unfortunately, due to the need to suppress the immune system, only a small proportion of these therapies are effective.
Stem cell transplant is the latest method which can give patients with Diabetes new hope. Stem cells are different from other cells because they have the unique potential to become cells with special functions such as the insulin-producing beta cells found in the pancreas.
All in all, obesity can lead to Diabetes and we should try stem cell transplant if diagnosed with Diabetes.
Can Obesity Cause Diabetes
With the rapid development of the society and the improvement of life quality, some people have more body weight. And some may even develop into Diabetes. Diabetes is a kind of dangerous disease, which can accompany people in the whole lifetime. Is there any relationship between obesity and Diabetes? Yes. In this passage, we will mainly introduce you how obesity leads to Diabetes.
Firstly, as for those with increased body weight, because the adipocyte becomes fat, the density of insulin receptor in adipocyte becomes smaller, the sensibility to insulin decreases, which leads to high blood glucose. To stop the blood glucose from rising, patients will spare no effort to work and relieve more insulin, which can lead to hyperinsulinemia. With time passing by, insulin becomes tired, the function of which declines. The level of insulin in blood declines, and the blood sugar increases, which even leads to diabetes.
Secondly, for people who are heavier than the normal range, the amount of exercise will generally decrease, which lead to a fact that the body weight increase further. In addition, when people with obesity have less exercise, the metabolism of sugar will also decrease, which leads to increased sugar level in blood.
Thirdly, obesity people usually have high blood pressure and hyperlipidemia. It is found out that high blood pressure and high fat level in the blood are dangerous factors which can lead to Diabetes. As a matter of fact, other investigation from abroad also shows that people who are fat are more likely to get Diabetes. So to prevent Diabetes, we should firstly control the intake of energy, take more exercise, thus preventing obesity.
What shall we do if people are diagnosed with Diabetes?
In type 1 diabetes, the body’s immune system becomes programmed to attack the beta cells, so the patient must take immuno-suppressant drugs to prevent this happening.
Doctors and scientists have tried to cure the disease through injections of pancreatic islet cells. Unfortunately, due to the need to suppress the immune system, only a small proportion of these therapies are effective.
Stem cell transplant is the latest method which can give patients with Diabetes new hope. Stem cells are different from other cells because they have the unique potential to become cells with special functions such as the insulin-producing beta cells found in the pancreas.
All in all, obesity can lead to Diabetes and we should try stem cell transplant if diagnosed with Diabetes.

Sunday, June 2, 2013

Diabetic Nephropathy 17 Years, on Dialysis

Diabetic Nephropathy is a secondary kidney disorder which is caused by long time diabetes. Diabetes is a disease which can lead to damage to all capillaries in the system due to long time high blood glucose. Kidney is an organ which will be damaged as well.
Long time Diabetes without enough insulin and with high blood glucose and immune dysfunction leads to a series of pathological changes of glomerular intrinsic cells, which causes broadening of glomerular basilar membrane, narrowing of lumen. It results in the shrinking of blood vessel, which causes ischemia and anoxia of kidney, damage of capillaries surrounding glomerular and tubules and further inflammation infiltration. It starts the process of renal fibrosis. Kidney fibrosis refers to healthy kidney intrinsic cells are replaced by large quantity of extracellular matrix which can develop into glomerulosclerosis and tubular necrosis.
Generally, after 10 to 20 years, many diabetics will develop into Diabetic Nephropathy and serum creatinine will rise. When serum creatinine rises to 450umol/L, patients with Diabetic Nephropathy will take dialysis. What can we do in this case?
As we mentioned in the above, Diabetic Nephropathy is caused by diabetes, so we should treat kidney disease as well as diabetes. Stem cell is the best therapy to treat diabetes till now.
The mechanism goes as follows: pancreas islet β cells are damaged, which leads to insufficient secretion of insulin. In this case, the blood sugar will increase. If this can not be treated or controlled well, it will lead to systematic disorder and a series of complications will occur as well. Stem cells can repair the damaged pancreas islet β cells, thus recovering the function of insulin. In this case, the secretion of insulin can turn normal and diabetes can recover consequently.
As for kidney disorder caused by diabetes, we should use Chinese Medicine when creatinine is not too high and dialysis doesn’t last for a long time. Chinese Medicine can improve the blood flow in the kidney, increase the amount of urine. It can also repair the damaged intrinsic cells in the kidney, thus reviving renal function.

5 Stages of Diabetic Nephropathy (DN)

Diabetic Nephropathy (DN) is a kind of secondary kidney disease which is caused by long time diabetes. Generally, it can be divided into 5 stages.
The first stage can also be called renal hypertrophy of diabetic glomerulus and high filtration stage. In this stage, only GFR increases. The UAE is normal. Generally, type 1 diabetes patients have this kind of change. After treatment, they can reverse.
The second stage can also be called asymptomatic renal damage stage. In this stage, intermittent microalbumin appears in urine. In this stage, renal structure has changed. GFR increases or stays in normal. Blood pressure is usually normal in this stage. This stage usually takes place 2 years after diagnosed with Diabetic Nephropathy (DN). Many patients can maintain in the stage and have a good prognosis.
The third stage is called early stage of Diabetic Nephropathy (DN). In this stage, continuous microalbumin appears. The kidney structure changed a lot. GFR is normal and blood pressure rises slightly. This stage usually takes place 10 to 15 years after diagnosed with Diabetic Nephropathy.
The fourth stage is called clinical Diabetic Nephropathy stage or dominant Diabetic Nephropathy stage. In this stage, patients can have a large amount of proteinuria, hypoalbuminemia and edema. GFR decreased progressively. Blood pressure increases obviously. Such symptoms appear 15 to 25 years after diagnosed with Diabetic Nephropathy.
The last stage is renal failure stage. In this stage, serum creatinine level and BUN (blood urea nitrogen) rises, which lead to azotaemia and renal failure. Patients can also be accompanied by high blood pressure, edema, poor appetite or anemia, and so on. If the serum creatinine rises as high as 445umol/L, patients need to take dialysis.
However, please do not worry once diagnosed with Diabetic Nephropathy for modern medical technology is developing at a rapid speed.

Why Diabetes Lead to Renal Damage

Renal damage caused by diabetes is called diabetic nephropathy, which is a secondary kidney disease which is due to long time diabetes. So realizing it, patients with Diabetes want to know why diabetes leads to renal damage and how to prevent diabetes leading to renal damage.
Firstly, Diabetes can make the walls of micro-blood vessels become fragile and tough. Gradually, the wall of micro-blood vessels become narrow and blocked. In the early stage, when blood flows through renal glomeruli, a large amount of nutritious substances will leak out such as albumin. Albumin is the important materials which can maintain the human body’s life. In normal condition, albumin can not leak out. When diabetes develops into diabetic nephropathy, albumin will leak out. With patient’ condition becoming more and more serious, there will be other kinds of molecules leaking out such as protein, red blood cells, white blood cells. In the end stage, with more and more renal glomeruli are damaged, renal damage will take place.
Secondly, patients with diabetes will ask how to prevent it from happening. The most important and effective way is to treat diabetes with stem cells. pancreas islet β cells are damaged, which leads to insufficient secretion of insulin. In this case, the blood sugar will increase. If this can not be treated or controlled well, it will lead to systematic disorder and a series of complications will occur as well. Stem cells can repair the damaged pancreas islet β cells, thus recovering the function of insulin. In this case, the secretion of insulin can turn normal and diabetes can recover consequently. Now stem cell transplant also has become
Thirdly, taking exercise regularly and keep low sugar diet are also necessary.

How Diabetes Leads to Diabetic Nephropathy

In China, about one out of ten people will develop into diabetes with the changing of eating habit and working style. According to the Centers for disease Control, over 17 million Americans have diabetes. Unfortunately, one third of them do not even realise that they have the disease. Approximately 45% of patients suffering from chronic kidney disease had diabetes as the major reason for this dreadful disease, where once the kidneys are damaged and unable to perform their filtration of impurities from blood, there is no recourse to medicinal cure, and the available options are dialysis (Filtering functions of kidney being substituted by a machine) or kidney transplant, where the donor and recipient have to undergo major surgery.
Link between diabetes and kidney disease goes as follows: Diabetes damages small blood vessels in the body. When the blood vessels in kidney are injured, kidneys lose their capacity to filter the impurities from blood properly. Body retains more water, salt and this results in increase in weight and swelling in the ankles. Urine contains protein. Waste materials start building up in the blood. Besides, diabetes damage nerves in the body. This causes difficulty in emptying bladder. There is a back-up pressure from the stored urine in the bladder, damaging the kidneys. Moreover, the stored urine in bladder causes infection.
The course of kidney disease: The kidney disease takes a longer time leading to kidney failure. Initially, small amounts of protein / albumin leaks into the urine. The filtration function of kidney remains normal during this period. As time passes, more albumin leaks into urine. This stage is known as 'overt diabetic nephropathy or macroalbuminuria. After this stage, filtration begins to drop. Body retains various wastes as filtration drops. Creatinine is one such waste and blood test for creatinine is used to estimate decline in kidney function. As the damage develops, blood pressure also rises.
Even though diagnosed with diabetic nephropathy, patients needn’t panic for there have been effective treatment measures to treat it.