The definition of renal parenchyma
According to the anatomical structure, kidney can be divided into renal
parenchyma and renal interstitium. Renal parenchyma is comprised of functional
unit (or nephron) and collecting duct. Renal interstitium is comprised of
interstitial cell and loose extracellular matrix. Nephron is the essential
structure and functional unit of the kidney and each human kidney contains about
more than one million nephrons. The essential components of the nephron include
the renal or malpighian corpuscle (glomerulus and Bowman capsule) and all
segments of the renal tubule, including: proximal tubule, the medullary
ascending and descending limbs, the distal tubule, but the collecting duct is
excluded.
Features of the vessels: Compared with the efferent arteriole, the afferent
arteriole is thick and straight, and the efferent arteriole is thin and long,
which forms certain capillary lumen pressure difference between the two, thus
that hydrostatic pressure of the glomerular capillary is higher than that of
other parts in our body, so it is good for the filtration function of the
glomerular capillary (Filtration function of the glomerulus).
Clinical manifestation
1. high blood pressure
High blood pressure caused by renal parenchymal lesion accounts for 5% to 10%
of all high blood pressure, which also ranks first among secondary high blood
pressure. The prognosis of high blood pressure caused by renal parenchymal
lesion is bad, which is also the most dangerous factor which can worsen the
chronic kidney failure.
2. Most patients with chronic parenchymal renal lesion have anemia, which is
caused by not one factor. For example, there are many toxins in the blood, which
will shorten the lifespan of red blood cell, thus causing anemia.
3. The lesion in eye ground is more serious, and patients are also likely to
have complication such as disease in heart and blood vessels.
4. Compared with primary high blood pressure, high blood pressure caused by
renal parenchyma disease are much easier to develop into progressive high blood
pressure or malignant high blood pressure. Its morbidity is also twice higher
than that of primary one. The prognosis is also not as good as the primary
one.
5. Patients with chronic parenchymal renal disease have abnormal urine test
report such as protein in urine, creatinine level and so on.
Wednesday, July 3, 2013
Tuesday, July 2, 2013
Symptoms in Four Stages of Renal Insufficiency
We definite the 4 stages of renal insufficiency mainly on the basis of serum
creatine level: compensation stage, discompensation stage, early stage of renal
failure, end stage of renal failure. The symptoms of each stage are as
follows:
In the first stage: compensation stage, there is nearly no symptom in clinic for the kidney has a strong ability of compensation. Because of this, symptoms will not occur. Even though some renal glomeruli are damaged, other remained renal glomeruli can still work and do more work to take place those which are damaged. The ability of secretion and electrolyte balance can also meet the need. In this stage, kidney can still function and work well, so we call it compensation stage. We should pay attention however that there has been damage in the kidney and the GFR has decreased. Kidney can still discharge metabolism product, balance of electrolyte, and so on.
The second stage is discompensation stage. In this stage, serum creatinine is 177～443umol/L. The damaged renal glomerulus increases, which accounts for about 60% to 75%. The secretion function has been damaged, blood urea acid increases as well. Kidney disease patients begin to have anemia, fatigue, weakness, lost body weight, and so on. If they suffer from water lost, infection or bleeding, the condition will develop faster. Kidney has difficulties in discharging metabolism.
The third stage is early stage of renal failure stage. In this stage, kidney fails and the serum creatinine is 443-707umol/L. There are more necrotic renal glomerulus. The damage in the kidney has become rather serious, accounting for 75% to 95%. The inner environment can not maintain stable. In addition, patients will get tired easily and will feel fatigue, and can not concentrate, etc. Urine at night becomes more. Renal fibrosis appears in renal tubules-renal parenchyma, renal blood vessels, which leads to serious damage in the kidney. As for the symptoms, kidney disease patients will have more obvious anemia, increased urine at night, and so on. Patients can also be accompanied by acidosis. So this stage can also be called azotemia.
In the end stage of renal failure, serum creatinine is more than 707umoll/L. In China, patients begin to take dialysis. The damaged renal glomerulus are more than 95%. Patients with kidney disease will also have serious vomiting, little urine, edema, high blood pressure and so on.
So regular screening is necessary, which can help us diagnose kidney damage as soon as possible. For the compensation of kidney, serum creatinine will not rise until the kidney is damaged more than half. Testing on urine or blood can show the abnormal level of albumin, beta 2 microalbumin, etc.
In the first stage: compensation stage, there is nearly no symptom in clinic for the kidney has a strong ability of compensation. Because of this, symptoms will not occur. Even though some renal glomeruli are damaged, other remained renal glomeruli can still work and do more work to take place those which are damaged. The ability of secretion and electrolyte balance can also meet the need. In this stage, kidney can still function and work well, so we call it compensation stage. We should pay attention however that there has been damage in the kidney and the GFR has decreased. Kidney can still discharge metabolism product, balance of electrolyte, and so on.
The second stage is discompensation stage. In this stage, serum creatinine is 177～443umol/L. The damaged renal glomerulus increases, which accounts for about 60% to 75%. The secretion function has been damaged, blood urea acid increases as well. Kidney disease patients begin to have anemia, fatigue, weakness, lost body weight, and so on. If they suffer from water lost, infection or bleeding, the condition will develop faster. Kidney has difficulties in discharging metabolism.
The third stage is early stage of renal failure stage. In this stage, kidney fails and the serum creatinine is 443-707umol/L. There are more necrotic renal glomerulus. The damage in the kidney has become rather serious, accounting for 75% to 95%. The inner environment can not maintain stable. In addition, patients will get tired easily and will feel fatigue, and can not concentrate, etc. Urine at night becomes more. Renal fibrosis appears in renal tubules-renal parenchyma, renal blood vessels, which leads to serious damage in the kidney. As for the symptoms, kidney disease patients will have more obvious anemia, increased urine at night, and so on. Patients can also be accompanied by acidosis. So this stage can also be called azotemia.
In the end stage of renal failure, serum creatinine is more than 707umoll/L. In China, patients begin to take dialysis. The damaged renal glomerulus are more than 95%. Patients with kidney disease will also have serious vomiting, little urine, edema, high blood pressure and so on.
So regular screening is necessary, which can help us diagnose kidney damage as soon as possible. For the compensation of kidney, serum creatinine will not rise until the kidney is damaged more than half. Testing on urine or blood can show the abnormal level of albumin, beta 2 microalbumin, etc.
Treat Renal Insufficiency with Stem Cell and Chinese Medicine
How to treat renal insufficiency without any side effect? In this article, we
will introduce a combination therapy of both western medicine and stem cell,
which can treat renal insufficiency effectively and have no side effects
compared with pure hormone or immunosuppressive agent. It is mainly Chinese
Medicine and stem cell.
Chinese Medicine is a natural herbal therapy applied externally on acupoint of lower back (kidney area). The herbal medicine is micronized into ten thousandths of its original size. Herbal bags containing dozens of herbal medicines are soaked previously in penetrants, and then placed on the lower back part. With the help of osmosis device, effective ingredients of herbal medicines will infiltrate into kidneys through the main and channels.
The main curative effect of this herbal therapy is to promote whole body blood circulation, and especially the blood circulation within the kidneys. If analyzed from cytology, when kidney function decline occurs, there are three types of cells in the kidneys. There are healthy cells that are overburdened: damaged but still reversible cells: and completely necrotic cells that have no function left. The necrosis is an absolute loss, but this herbal therapy helps removing blood stasis or thrombus, degrading extracellular matrixes, and dilating each level blood vessel to promote blood flowing into the kidneys. In this way, sufficient blood supply creates a great environment for the self-repairing of these damaged but still reversible cells, and prevents kidney function from further declining.
As we mentioned before, necrosis is an absolute loss of overall kidney function. And this is because kidney differs from other organs like the Liver in that once there is renal cell necrosis, the kidneys are incapable of regenerating more cells to replace these died ones. And, this is also why kidney failure is considered as irreversible.
However, stem cells can differentiate into kidney cells. Stem cells are original cells with multi-potential and multi-directional differentiation ability, which means that, after cultivation, stem cells can differentiate into functional cells of one specific organ, like the kidney. We take advantage of this very characteristic of stem cell in treating kidney function decline. Umbilical Mesenchymal Stem Cells Transplant and Cord Blood Stem Cell Transplant are adopted in our hospital, and they mainly differentiate into kidney parenchymal cells and kidney blood capillary cells separately. Stem cells are provided and cultivated by the hospital, and transfused into patient’s body through intravenous drip. So, no surgical operation is needed.
In summary, this treatment is a conservative treatment method, and aims at protecting and restoring overall kidney function to a more satisfying level to prolong or avoid the necessity of dialysis or kidney transplant. For more information about how renal insufficiency is treated, please feel free to consult the service online or leave a message about your own information.
Chinese Medicine is a natural herbal therapy applied externally on acupoint of lower back (kidney area). The herbal medicine is micronized into ten thousandths of its original size. Herbal bags containing dozens of herbal medicines are soaked previously in penetrants, and then placed on the lower back part. With the help of osmosis device, effective ingredients of herbal medicines will infiltrate into kidneys through the main and channels.
The main curative effect of this herbal therapy is to promote whole body blood circulation, and especially the blood circulation within the kidneys. If analyzed from cytology, when kidney function decline occurs, there are three types of cells in the kidneys. There are healthy cells that are overburdened: damaged but still reversible cells: and completely necrotic cells that have no function left. The necrosis is an absolute loss, but this herbal therapy helps removing blood stasis or thrombus, degrading extracellular matrixes, and dilating each level blood vessel to promote blood flowing into the kidneys. In this way, sufficient blood supply creates a great environment for the self-repairing of these damaged but still reversible cells, and prevents kidney function from further declining.
As we mentioned before, necrosis is an absolute loss of overall kidney function. And this is because kidney differs from other organs like the Liver in that once there is renal cell necrosis, the kidneys are incapable of regenerating more cells to replace these died ones. And, this is also why kidney failure is considered as irreversible.
However, stem cells can differentiate into kidney cells. Stem cells are original cells with multi-potential and multi-directional differentiation ability, which means that, after cultivation, stem cells can differentiate into functional cells of one specific organ, like the kidney. We take advantage of this very characteristic of stem cell in treating kidney function decline. Umbilical Mesenchymal Stem Cells Transplant and Cord Blood Stem Cell Transplant are adopted in our hospital, and they mainly differentiate into kidney parenchymal cells and kidney blood capillary cells separately. Stem cells are provided and cultivated by the hospital, and transfused into patient’s body through intravenous drip. So, no surgical operation is needed.
In summary, this treatment is a conservative treatment method, and aims at protecting and restoring overall kidney function to a more satisfying level to prolong or avoid the necessity of dialysis or kidney transplant. For more information about how renal insufficiency is treated, please feel free to consult the service online or leave a message about your own information.
Is Anemia Serious for Renal Failure?
Is anemia serious for renal failure? In this passage, we will mainly
introduce it from the reason why patients with renal failure.
When patients develop into kidney failure stage, the secretion of hemopoietin which is short for EPO, decreases. So the hematopoietic function of marrow declines. EPO is produced in the kidney, which arrives marrow through blood circulation and then adjusts the marrow to produce red blood cells. In chronic kidney failure stage, the production of EPO is not enough, which leads to the low level of red blood cells in the body, thus causing anemia.
Is anemia serious for renal failure? It can be divided into three cases:
Firstly, as for adults, slight anemia is not serious. However, if anemia develops serious, it will lead to insufficiency of blood in organs and tissues, which will influence the function of tissues and organs. In addition, long time anemia will lead to the increased size of heart.
2. As for children anemia in renal failure, we should take effective treatment as soon as possible, which or else will influence their growth.
3. As for women, if they are suffering from anemia in renal failure, their skin will look yellowish, and their hair will have no nutrition. In addition, they will also suffer from dark skin.
How to adjust anemia fundamentally? The effective measures are to repair the kidney function. According to cytology, any kidney damage belongs to the damage of intrinsic cells. So we should aim at the repair of kidney intrinsic cells, which western medicines are difficult to reach.
In our Hospital, Chinese Medicine is applied. Chinese Medicine can repair damaged intrinsic cell in the kidney and reverse the insufficiency of blood fundamentally for Chinese Medicine contains kinds of nutritious traditional Chinese herbs and active materials, which can extend blood vessels, thus improving the blood circulation in all levels including micro-blood vessels.
When patients develop into kidney failure stage, the secretion of hemopoietin which is short for EPO, decreases. So the hematopoietic function of marrow declines. EPO is produced in the kidney, which arrives marrow through blood circulation and then adjusts the marrow to produce red blood cells. In chronic kidney failure stage, the production of EPO is not enough, which leads to the low level of red blood cells in the body, thus causing anemia.
Is anemia serious for renal failure? It can be divided into three cases:
Firstly, as for adults, slight anemia is not serious. However, if anemia develops serious, it will lead to insufficiency of blood in organs and tissues, which will influence the function of tissues and organs. In addition, long time anemia will lead to the increased size of heart.
2. As for children anemia in renal failure, we should take effective treatment as soon as possible, which or else will influence their growth.
3. As for women, if they are suffering from anemia in renal failure, their skin will look yellowish, and their hair will have no nutrition. In addition, they will also suffer from dark skin.
How to adjust anemia fundamentally? The effective measures are to repair the kidney function. According to cytology, any kidney damage belongs to the damage of intrinsic cells. So we should aim at the repair of kidney intrinsic cells, which western medicines are difficult to reach.
In our Hospital, Chinese Medicine is applied. Chinese Medicine can repair damaged intrinsic cell in the kidney and reverse the insufficiency of blood fundamentally for Chinese Medicine contains kinds of nutritious traditional Chinese herbs and active materials, which can extend blood vessels, thus improving the blood circulation in all levels including micro-blood vessels.
Monday, July 1, 2013
Immune Treating Plan for Renal Failure in Our Hospital
Most of kidney diseases are caused by immune disorder, on the basis of which,
we mainly use immunotherapy in our Hospital, which includes Chinese medicine and
stem cell, etc. In renal failure stage, there are both damaged intrinsic cells
and necrotic cells in the kidney as well as the healthy ones.
Firstly, after arriving hospital, we will apply the professional tests and our tests can find the accurate types of immune complex and the kidney lesion. The treatment must according to the accurate tests, then we can ensure the effects of treatment.
Secondly, we will apply the medicines to stop the appearing of immune complex, then avoid the further damage on kidney cells.
Thirdly, to the damaged kidney tissue, we will apply Chinese medicine to repair the kidneys.
Fourthly, in order to secure the effects, it is necessary for patients to undergo a systematic dialysis. We have many kinds of dialysis and the most advanced technology for purifying blood so that there is a favorable environment for the medicines. At clinic, after the immune clearance, immunoadsorbent technics, Hemoperfusion and so on, the treating effects can improve to 60%. You know, the common dialysis can only eliminate the big molecule in blood, but the new thchnology can help eliminate the small, middle and big molecule toxins, so the blood can be purified completely.
Fifthly, to renal failure patients, there are some kidney cells which are necrotic, no treatment can make them live, but we can use new cells to replace them, that is Stem cells. So, if we want to improve renal function, we must take stem cells.
Sixthly, once the patients receive treatment here, there will be his records in hospital. The working staff will keep close in touch with them to guide them take treatment regularly and give suggestions for life-long.
The above are the general treating plan and patients will have his specific treating plan after consultation of our experts when he arrives hospital. For more information about the immunotherapy in our Hospital, please consult us online or email us.
Firstly, after arriving hospital, we will apply the professional tests and our tests can find the accurate types of immune complex and the kidney lesion. The treatment must according to the accurate tests, then we can ensure the effects of treatment.
Secondly, we will apply the medicines to stop the appearing of immune complex, then avoid the further damage on kidney cells.
Thirdly, to the damaged kidney tissue, we will apply Chinese medicine to repair the kidneys.
Fourthly, in order to secure the effects, it is necessary for patients to undergo a systematic dialysis. We have many kinds of dialysis and the most advanced technology for purifying blood so that there is a favorable environment for the medicines. At clinic, after the immune clearance, immunoadsorbent technics, Hemoperfusion and so on, the treating effects can improve to 60%. You know, the common dialysis can only eliminate the big molecule in blood, but the new thchnology can help eliminate the small, middle and big molecule toxins, so the blood can be purified completely.
Fifthly, to renal failure patients, there are some kidney cells which are necrotic, no treatment can make them live, but we can use new cells to replace them, that is Stem cells. So, if we want to improve renal function, we must take stem cells.
Sixthly, once the patients receive treatment here, there will be his records in hospital. The working staff will keep close in touch with them to guide them take treatment regularly and give suggestions for life-long.
The above are the general treating plan and patients will have his specific treating plan after consultation of our experts when he arrives hospital. For more information about the immunotherapy in our Hospital, please consult us online or email us.
How to Treat Chronic Kidney Disease Stage 3
How to treat Chronic Kidney Disease stage 3?Firstly, we should know the
condition of stage 3 chronic kidney disease. In this stage, GFR short for
glomerular filtration rate falls to 30 to 59. Kidney is damaged. High blood
pressure or hypertension takes place. The absorption of calcium decreases. The
discharge of phosphorus decreases. PTH rises obviously. The metabolism of
lipoprotein changed. The intake of spontaneous protein decreases. In addition,
people also have renal anemia which is caused by long time kidney damage as well
as left ventricular hypertrophy.
How to treat chronic kidney disease stage3? What treatment measures should we take? In the world, most kidney diseases are caused by immune problem. On the basis of this, immunotherapy is researched out in our Hospital, which makes full use of both western medicine and Chinese herbs. It has little side effects and can treat chronic kidney disease stage 3 fundamentally. The immunotherapy can be mainly divided into 6 steps. The immune complex deposits onto the kidney, which leads to a series of immune reaction, thus causing kidney damage.
So in the first step, the immune diagnosis, we can help patients figure out the specific damage in each patients such as the type of the immune complex, the exact place of it, and the amount of it, which can give an important clue for the treatment in clinic.
Next, patients with stage 3 chronic kidney disease should have blood purification for kidney is damaged and there must be toxins in the blood such as creatinine, urea acid and urea nitrogen, etc. After this step, the immune complex which exists in the blood can be cleared away.
Then, there is still immune complex on the kidney, which will lead to further immune reaction and damage in the kidney. We should try our best to clear it away, thus treating chronic kidney disease stage 3 fundamentally. After these, the symptoms above mentioned will be relieved from root such as high blood pressure, anemia, etc.
We do not clear them away immediately. We use medicine to inhibit the immune reaction firstly, which can stop the damage to the kidney. Then, we use other medicine to let the body adapt the existence of immune complex. In this step, some western medicine which has little side effect is applied.
In the immune adjustment and immune protection step, Chinese Medicine is applied, which can clear away the immune complex onto the kidney and repair the damaged intrinsic cells. In stage 3 chronic kidney disease, there are necrotic cells in the kidney and stem cells can differentiate into new ones, thus rebuilding renal structure and increase the immune ability. If the immune system turns normal, it can swallow the immune complex and clear them away from the body as normal persons and stage 3 chronic kidney diseases can be treated fundamentally.
How to treat chronic kidney disease stage3? What treatment measures should we take? In the world, most kidney diseases are caused by immune problem. On the basis of this, immunotherapy is researched out in our Hospital, which makes full use of both western medicine and Chinese herbs. It has little side effects and can treat chronic kidney disease stage 3 fundamentally. The immunotherapy can be mainly divided into 6 steps. The immune complex deposits onto the kidney, which leads to a series of immune reaction, thus causing kidney damage.
So in the first step, the immune diagnosis, we can help patients figure out the specific damage in each patients such as the type of the immune complex, the exact place of it, and the amount of it, which can give an important clue for the treatment in clinic.
Next, patients with stage 3 chronic kidney disease should have blood purification for kidney is damaged and there must be toxins in the blood such as creatinine, urea acid and urea nitrogen, etc. After this step, the immune complex which exists in the blood can be cleared away.
Then, there is still immune complex on the kidney, which will lead to further immune reaction and damage in the kidney. We should try our best to clear it away, thus treating chronic kidney disease stage 3 fundamentally. After these, the symptoms above mentioned will be relieved from root such as high blood pressure, anemia, etc.
We do not clear them away immediately. We use medicine to inhibit the immune reaction firstly, which can stop the damage to the kidney. Then, we use other medicine to let the body adapt the existence of immune complex. In this step, some western medicine which has little side effect is applied.
In the immune adjustment and immune protection step, Chinese Medicine is applied, which can clear away the immune complex onto the kidney and repair the damaged intrinsic cells. In stage 3 chronic kidney disease, there are necrotic cells in the kidney and stem cells can differentiate into new ones, thus rebuilding renal structure and increase the immune ability. If the immune system turns normal, it can swallow the immune complex and clear them away from the body as normal persons and stage 3 chronic kidney diseases can be treated fundamentally.
How to Improve Kidney Function Naturally
How to improve kidney function naturally? Generally, besides treatment, there
are some natural ways which can help relieve kidney disease which goes as
follows:
1. rest and massage
When people can not have enough rest, the glomeruli in the kidney will do more work and get tired after a long time there appears insufficiency of blood and oxygen. In this case, the normal glomeruli will do more work to replace the damaged one.
To remit, patients with kidney disease need more rest, which can make the whole body relaxed. Massage is a good way to help the intrinsic cells relaxed for it can promote the blood circulation, thus improving the micro-circulation at the same time and relieving the insufficiency of blood and oxygen in the kidney. After this, some damaged intrinsic cells in the kidney can turn normal.
2. limit the sexual activity
Among end stage renal disease patients, women on dialysis are much easier to have sexual dysfunction. 84% of all women and 55% of sexually active women in the study experienced sexual problems. In this case, sexual activity will worsen kidney function.
3. Ayurveda therapy
It is aimed at the systematic treatment, and it treats the body, soul and heart as a whole system, the emphasis of which is the harmonious condition of people and nature. It focuses on changing the life attitude and adjusts the unbalance of the body. In India, the government attach more importance on Ayurveda therapy and it really plays an important role in treating disease including kidney diseases.
4. Acupuncture
It is used to stimulate shenyu point, which can increase the secretion function. The discharge amount of phenol red becomes more obviously. The red blood cells, white blood cells and protein in urine turn less and even disappear. Blood pressure declines, edema relieves as well accordingly.
5. Chinese medicine
It has a long history and is abstracted from herbs in nature, which has no side effect and can improve the blood circulation and repair the damaged intrinsic cells in the kidney. In recent years, to make it more convenient, Chinese Medicine is created, which is more effective and convenient and easier to operate.
1. rest and massage
When people can not have enough rest, the glomeruli in the kidney will do more work and get tired after a long time there appears insufficiency of blood and oxygen. In this case, the normal glomeruli will do more work to replace the damaged one.
To remit, patients with kidney disease need more rest, which can make the whole body relaxed. Massage is a good way to help the intrinsic cells relaxed for it can promote the blood circulation, thus improving the micro-circulation at the same time and relieving the insufficiency of blood and oxygen in the kidney. After this, some damaged intrinsic cells in the kidney can turn normal.
2. limit the sexual activity
Among end stage renal disease patients, women on dialysis are much easier to have sexual dysfunction. 84% of all women and 55% of sexually active women in the study experienced sexual problems. In this case, sexual activity will worsen kidney function.
3. Ayurveda therapy
It is aimed at the systematic treatment, and it treats the body, soul and heart as a whole system, the emphasis of which is the harmonious condition of people and nature. It focuses on changing the life attitude and adjusts the unbalance of the body. In India, the government attach more importance on Ayurveda therapy and it really plays an important role in treating disease including kidney diseases.
4. Acupuncture
It is used to stimulate shenyu point, which can increase the secretion function. The discharge amount of phenol red becomes more obviously. The red blood cells, white blood cells and protein in urine turn less and even disappear. Blood pressure declines, edema relieves as well accordingly.
5. Chinese medicine
It has a long history and is abstracted from herbs in nature, which has no side effect and can improve the blood circulation and repair the damaged intrinsic cells in the kidney. In recent years, to make it more convenient, Chinese Medicine is created, which is more effective and convenient and easier to operate.
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