Nephrotic syndrome in the early treatment effect is good!

Nephrotic syndrome in the early treatment effect is good! Hormone drug curative effect is distinct, its usage and dosage needs depends on the progression of nephrotic syndrome patients.
It is worth noting: nephrotic syndrome is divided into primary and secondary two. Secondary nephrotic syndrome for many reasons, mainly including rheumatism, tumor, infection, drugs, etc. Minor lesions, mesangial proliferation and mesangial capillaries proliferative (membrane), membranous nephropathy and focal segmental sclerosis type.
Nephrotic syndrome should be treated as early as possible, because we all know, most of the initial condition is not very heavy disease, treatment is relatively easy, this period is called the best period of treatment, and nephrotic syndrome. The disease found that early diagnosis and early treatment is very necessary, most patients with nephrotic syndrome at the face for the performance of double lower limbs swelling, or reduced the volume of urine, or abdominal distension, appetite drops, etc. We can found that urine protein urine routine + + + ~ + + + +, 24 hours urinary protein quantitative > 3.5 g, albumin in plasma < 30 g/L. The basic clear diagnosis.
Mainly for hormone therapy in the treatment of primary nephrotic syndrome, the sensitive degree of different pathological type for hormone is different also, supplemented by cytotoxic type of immunosuppressant therapy when necessary, and symptomatic treatment. Note: hormone therapy should follow "beginning to foot, slowly, reducing maintain longer" principle. Many patients due to reduced too fast, keep time too short, often leads to disease recurrence. Hormone decrement, therefore, should be conducted under the guidance of a doctor.
Early membranous nephropathy: 60% 70% after active treatment can alleviate hormone and cytotoxic drugs. 2. The mesangial capillaries nephritis, focal segmental glomerular sclerosis and severe mesangial proliferative glomerulonephritis, curative effect is poor. In treatment, I believe many readers for hormone drug therapy will not feel strange, because its are widely used in the clinical treatment in the treatment of various diseases, and hormone therapy is also as one of the most common method of the treatment of nephrotic syndrome.
Usage and dosage of hormone is not a constant, should depend on kidney in the patient's condition. Starting quantity foot: commonly used drugs for prednisone 1 mg/kg. D, since morning suit, oral 8-12 weeks, most physicians advocate domestic the largest amount of less than 60 mg/d. Slowly decreasing dosage: every 1 to 2 weeks after adequate treatment reduce the dosage of 10 ℅, when reduced to 20 mg/d symptoms easily repeatedly, should be more slowly reduced. Long-term to maintain: finally with the minimum effective dose (10 mg/d), to maintain about half a year.
Hormone can treat many diseases, but it also is not everything, some diseases treated with hormone treatment not only not effect, often have the opposite effect is aggravating patient condition. Pathological types, treatment is also different, therefore, renal biopsy pathological changes clearly it is very important. Nephrotic syndrome is a common disease, frequently-occurring disease and renal medicine diagnosis is relatively easy, but to identify the distinction between primary and secondary nephrotic syndrome.
According to the patient response to hormonal therapy, it can be divided into "hormone sensitivity (medication after 8-12 weeks NS remission)", "hormone dependent (hormones), to a certain extent recurrence", "hormone resistance (hormone therapy effect"), for the latter two combined with immunosuppressive therapy. Early patient general condition is light, if timely treatment, the illness under control, which can effectively reduce the kidney in injury to the patient, the patient can usually achieve good prognosis.
Nephropathy (small lesions and mild mesangial proliferative glomerulonephritis: sensitive to hormone; Poor effects and the recurrent author cytotoxic drugs can also be used. The hormone drug therapy is the most common method in the treatment of nephrotic syndrome patients, alleviate hormone is drug of choice for nephrotic syndrome, commonly used glucocorticoid steroid hormone preparations, such as prednisone, clinical effect is significant.
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