The symptoms of Uremia

Uremia is the generic terms of a series of toxic symptoms appeared in the End Stage Renal Failure. During the period of Uremia, besides the further aggravation of the following symptoms, such as disorder of water, electrolyte and acid-base balance as well as anemia, bleeding tendency, hypertension and so on, patients may occur the clinical manifestations of toxication caused by multiple system organ failure and material metabolism failure.
Ⅰ. The Symptoms of Neurological System
The Symptoms of Neurological System are main symptoms of Uremia. In its early stage, the patients often have the symptoms such as: dizziness, headache, fatigue, slip of intellect and memory, etc. Along with the illness condition changing worse, other symptoms would be also appeared, such as fidgets, muscle tremor, hyperspasmia and finally it may develop into apatheia, drowsiness and coma. The occurring of these symptoms is related to the following factors:
a. Accumulation of some toxicants may arouse the degeneration of nerve cells;
b. Disorder of electrolyte and acid-base balance.
c. Cerebral angiospasm, anoxia and the increasing of capillary permeability caused by Renal Hypertension may lead to the degeneration of cranial nerve cells and Encephaledema.
Ⅱ. The Symptoms of Gastrointestinal System
The earliest gastrointestinal symptom of the Uremia patients is inappetence or dyspepsia. When their illness condition changing worse, they will have anorexia, nausea, vomit or diarrhea. The occurrence of these symptoms may have the relation with the inflammation or multiple and superficial aphtha which are caused by the stimulation to Gastrointestinal Mucosa of Ammonia decomposed by urease of bacterial inside intestinal tract and urea. The patients are always combining with Gastrointestinal Bleeding. Besides, nausea, vomiting are also related with dysfunction of central nervous system which is acted on by toxins.
Ⅲ. The Symptoms of Cardiovascular System
Patient with Chronic Renal Failure may occur heart failure, arrhythmia and Myocardial Damage due to the actions of Renal Hypertension, Acidosis, Hyperkalemia, Retention of sodium and water, Anemia and toxicant material. Because of the stimulation of urea as well as Uric Acid, the patients may also occur Aseptic pericarditis and feel precordium pain and pericardiac friction sound can be heard when taking physical examination. There are cellulose and blood effusion in cavum pericardiale when the patients are in serious condition.
Ⅳ. The Symptoms of Respiratory System
When the patients are suffering from acidosis they may have a slow and deep breath, when in serious condition, the patients may have particular Kussmaul breath, in which has foul smell of urine, the reason is because of bacterial decomposition of urea to form of ammoniac. The serious patient may occur the lesion of pulmonary edema, fibrinouspleurisy or pulmonary calcification and so on. Pulmonary Edema has the relation to these factors, such as cardiac failure, Hypoproteinemia, retention of sodium and water and so on. Fibrinouspleurisy is a kind of inflammation caused by the stimulation of urea; pulmonary calcification is formed by the deposition of calcium phosphate in lung tissue.
Ⅴ. The Symptoms of the Skin
Skin itching is the common symptom of Uremia patient, which may be caused by toxic substances stimulation on skin receptor. Some people considered that it has the relation with the Secondary Hyperparathyroidism, because if it has resected, the pain would be relieved immediately. In addition, the patient’s skin may occur dryness and desquamation and tawny color. It was considered that the change of skin’s color is because of the increasing of urochrome, but now it is proved that the main pigment of skin is melanin when checked up by absorption spectrophotometer. On the exposure part of the skin, slight bruise can arouse skin ecchymosis. Because the urea of the sweat has a high density, so there are white crystals on the opening part of sweat gland, which is called Urea Frost.
To Treat Uremia with Stem Cell Transplant
Usually, dialysis and kidney transplant are clinically adopted to treat uremia. Dialysis means that uremia patients have an artificial kidney which functions as the kidneys to excrete wastes and extra water out of body. It can make the original kidneys wither and become obsolete in the end. The problem of kidney transplant is that at first the expenditure is high and then patients have to try to prevent the complications after transplant. Finally they have to take medicines for rejection. To solve these problems, nephrologists recommend Stem Cell Transplant. Clinical practice has proven that Stem Cell Transplant is effective and convenient in uremia treatment.
Chinese Medicine , Absorption-focus Blood Purification and Stem Cell Transplant—all the three therapies combine with each other to treat uremia. Among them, Stem Cell Transplant therapy is outstanding in uremia treatment. It contributes to the five curative functions including blocking, adsorption, purification, restore and reconstruction.
Stem cells have the self-renewing ability and the potential of differentiating into functional cells of various tissues to restore the damaged intrinsic cells as a result the damaged kidneys recover. Through the interaction between cells and producing cell factors, the proliferation of T cells and the immune reaction is inhibited to reconstruct the immunity. Stem cells can differentiate into kidneys cells, muscle cells, lung cells, osteoblasts and chondrocytes, and reach the lesions through perfusion to restore the damaged cells. Finally the renal function is restored.
Uremia patients have to choose an effective therapy to fundamentally treat uremia. Stem Cell Transplant can not lonely protect the remaining nephrons but also restore the damaged nephrons. Finally, the renal function is recovered to some extent.