Treat IgA Nephritis with Micro-Chinese Medicine Osmotherapy

How to treat IgA Nephritis with Micro-Chinese Medicine Osmotherapy? IgA glomerulonephritis is a kind of glomerulus which is characterized by the fact that recurrent gross hematuria (or Microscopic hematuria) and mesangial cell increase, and stroma expland, meanwhile, with IgA widely depositing. Besides, IgA glomerulonephritis can also be refered to as IgA-IgG Mesangium sedimentary nephritis and IgA mesangium nephritis,etc.
[Epidemiology]
The reports of the incidence from all over the world quite differ from each other, the most frequent area of which is believed to be situated in the West Pacific Ocean. Of the confirmed biopsy, Japan is reported to take up 50 %, the Europe about 10% to 30%, and America less than 2%.and the reports from China varies from each other as well, accounting for 20% to 30%. It is obvious that the result is impacted by the native renal biopsy indications and urine census. For instance, 5% in Britain. Neverthless, a group of asympomatic hematuria biopsy from Scotland go up to 37%.the disease is more common in men and male to female ratio is about 2:1.There are also differences between races. For example, the Indians dwelling in New Mexico take up 35%, while it is very rare in the black. although it is found out that the IgA 2m(1)in the black is obviously low than that in the white, it has not been confirmed that it is definitely connected with the low incidence.
Since 1998, it is indicated in some reports that the disease tend to be a familial one, and at least that there exits genetic predisposition in some patients with chronic IgA nephropathy. HLA have analysed that it is connected with BW35and DR4. a recent group of analysis about ESRF caused by IgA point out that B 27 and DR1 are on the increase while DR 2 is on the decline.
[Clinical manifestation ]
A typical case go as follows: it took the patients several hours to two days to have gross hematuria after infected in the upper respiratory tract. The symptom lasts for several hours to several days, some even up to 1 week. The total number of such patients accounts for about 40% to 50%, slightly higher in children. Some individuals can suffer severe backache and stomachache, which may be related to intestinal IgA vasculitis. The other common manifestation of this disease are asymptomatic hematuria or proteinuria , accounting for 30 % to 40%.20% to 25% of the above – mentioned may encounter gross hematuria one or more times during the process.
Nephrotic syndrome can be found in 5% to 20% of patients, most of whom are children and youngsters. It is a type of DBPH with glomerulosclerosis sometimes. In addition, at times the phenomenon that mainly refers to Mesangial IgA deposition can also appear in the minimal change nephropathy, which is characterized by foot process fusion. Some less than 10% of the patients represent acute renal failure, and all of them can relieve themselves, 20% to 25% of whom are required to be dialyzed due to the NCGN. In the procedure, patients that are subjected to Nitrogen retention of quality form about 25%.
[Auxiliary examination]
Microscopic hematuria’s urine RBC are chiefly abnormal. 50% of the patients’ Serum IgA increase, but this phenomenon has no connection with the disease. The density of lambda light chain in Serum IgA increases. It is not worthwhile to test Urinary immunoglobulin. Most of the blood complement work well. Some elements or factors of the complement may decrease, which was mainly found in patients who is likely to have family disease.
However, it is not worth diognosing. In about half patients, the index of IgA- fibronectin gathered objects may have a transient increase. It contributes to the distinguish of other kidney disease, but it is not beneficial to the progress of itself. So has no diagnostic value, as well. 10%-15% of the patients may have increased IgA circulating immune complexes. 32% of patients had increased levels of IgA rheumatoid factor. A number of immunological parameters, including viruses and food antigens, antibodies, Tcell subsets, HLA locus antigens determination results may have changed, but it has no diagnostic value, too. In the biopsy of forearm palmar skin, 50% of the patients can be found deposition of IgA and C3, etc in their capillaries.
[Prognosis]
The disease may have spontaneous remission, which take up about 4% to 20%. Each year, about 1% to 2% of the patients get caught into the end stage of renal failure. It is shown that 80% to 90% of the patients can survive for 10 years, according to the statistic analysis from life table. It is estimated that about 30 of the patients will deteriorate into uremia person. And others will be sufferring persistent hematuresis or proteinuria. The elements which caused the poor prognosis are as follows: when they fell ill , they also had suffered from renal insufficiency,
proteinuria more than 1.5g/d, high blood pressure, as well as without gross hematuria; It is detected that there exist symptoms in the renal biopsy, such as glomerular, interstitial fibrosis, Violations of glomerular capillary, diffuse hyperplasia and diffuse crescent formation, etc.
[Therapeutic measures]
So far, doctors in western countries haven’t studied a satisfactory therapeutic schedule. They haven’t reach an agreement on the issue whether immunosuppressive is injected when adrenocortical hormone is used for the patients with progressive renal impairment. It is shown in the recent data that it is effective to use adrenocortical hormone every two days for the patients with Proteinuria more than 1g/d, which is beneficial to Proteinuria. What is more, it may alleviate proteinuria to the minimal change nephropathy with IgA deposition. The amalgamative use of Cyclophosphamide PanShengDing and HuaFuLin can relieve Proteinuria, and has no impact on GFR; The amalgamative use of CysA can also reduce Proteinuria, but it meanwhile reduce creatinine clearance. The curative
effect of the medicine such as Phenytoin, anti-platelet drugs, anthocyanin disodium, diphenyl hydantoin, etc, is not confirmed. Although it is reported that urokinase can protect the GFR, however, it has not been demonstrated yet.
Cutting off the tonsil is beneficial to those whose are having been suffering the recurrent tonsillitisn; Antibiotics ,
Which can prevent and treat infection, fortunately can be helpful to those who are suffering acute nephritis syndrome and acute renal failure. It is represented from a smaller series of observation that using fish-oil preparations can reduce albuminuria and increase glomerular filtration rate. Patients suffering from serious chronic IgA nephropathy can prevent the glomerular filtration rate from dropping, while being injected with HDIVID via vein,
So that blood urine and proteinuria can be ameliorated .But the disease will revive while the patients is not under treatment. For those who have had high blood pressure and severe proteinuria, ACEI can gear down the glomerular filtration rate, and decrease the proteinuria. Therefore, when it comes to the severe chronic IgA nephropathy, ACEI is the priority , which is aimed at downgrading blood pressure. However it is not clear whether ACEI is efficient to those
Whose blood pressure is in good condition.
After the end- stage patients accept the kidney transplant, there appears IgA deposition in the mesangium area of the transplanted kidneys. If the doner has subclinical chronic IgA nephropathy, after his kidneys are translated into a patient who has non- chronic uremia person, IgA deposition in the mesangium area will disappear in a minute. It is not certain that the progressive renal failure will take place when the transplanted kidneys meet the recurrent chronic IgA nephropathy. Nevertheless, the Immunosuppressive therapy which followed the transplantion, including CysA, can not keep them from growing. For the transplanted kidneys from corpse, 87% of them can survive 1year, and 77% 3years. Yet for some exceptions that have anti-IgA antibodies in HLA antigen, 100%of the patients can survive 2years. It is believed that the above-mentioned antibodies make great contributions to the survival.
It is proved by the clinical practice that Chinese Medicine has efficient effect on chronic IgA nephropathy. With this method, the common causes of kidney disease and uremia are refined, which refer to that the deficiency of the pneuma is the origin , and moist heat is the obstacle. It comes to an conclusion that the corporate principle is to enhance pneuma, and expel the moist heat. Afterwards, the high-tech micro cartivation is adopted. Based on the original treatment, a specific therapeutic methods of kidney disease come into being, accompanied by bioactive changing, the purpose of which is to promote blood circulation and remove. obstruction in channels.
The characteristics are as follows: it focuses on the kidney variable organization. It can find out the diseased tissue, remove immune complex and the slough thoroughly, and the effect is persistent. It is an creative treatment. The iateria functions in the way that it can promote blood circulation and remove obstruction in channels.